posted by admin on March 23, 2009

Is breast-feeding contraindicated while taking Prozac? Yes. Like many drugs, Prozac and its metabolite, norfluoxetine, are excreted in the mother’s milk. Since it is uncertain what temporary or final effect this would have on an infant, mothers who intend to nurse their babies should not take Prozac or other antidepressants. Prozac and other antidepressants are effective in treating post-partum depression, but mothers who take these medications should not nurse.

Is it safe to drive the car while on Prozac? Because several classes of psychoactive medications may at one time or another impair judgment thinking or motor skills, people who are beginning treatment with any antidepressant should be advised to avoid driving a car or operating hazardous machinery until they and their doctors are reasonably certain mat their illness is stabilized and their performance is not affected.

The period for not driving or operating machinery is during the severely depressed phase of the illness. When the patient has been stabilized, the depression has lifted, and the dosage of the drug has been established, the patient can usually drive.

What medications, besides psychiatric drugs, must be used cautiously or not at all while taking Prozac? Theoretically, two drugs may require particular caution until all of the data are in: the blood thinner Coumadin (warfarin) and some Digitalis-related drugs taken for heart failure. Those drugs, like Prozac and other SSRIs, are tightly bound to plasma proteins. Administering Prozac along with either of these medications may in theory alter their plasma concentrations, with potentially serious results.

However, contrary to these expectations, a single clinical scientific study looking at the interactions between Prozac, Coumadin, Diuril, Orinase, Valium, and diazepam found that Prozac had little effect on the actions of those drugs. Further drug interaction studies are needed.

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